High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma

ABSTRACT:

Background

Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.

Methods

The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunostaining. Inhibition of SERPINE2 expression by small interfering RNA (siRNA) was detected by quantitative PCR. Cell number assays and cell apoptosis assays were performed to clarify the cell-autonomous function of SERPINE2 in A549 and PC9 lung cancer cells.

Results

The overall survival of patients with high SERPINE2 expression was significantly worse than that of patients with low SERPINE2 expression (P?=?0.0172). Multivariate analysis revealed that SERPINE2 expression was an independent factor associated with poor prognosis (P?=?0.03237). The interference of SERPINE2 decreased cell number and increased apoptosis in A549 and PC9 cells

Conclusion

These results suggest that SERPINE2 can be used as a novel prognostic marker of lung adenocarcinoma.

SUBMITTER: Dokuni R 

PROVIDER: S-EPMC7737331 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature