Dataset Information

Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events.

ABSTRACT:

Background

Type 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has been shown to be increased in T2D plaques and suggested to contribute to plaque ruptures. Despite intensified statin treatment during the last decade the higher risk for events remains. Here, we explored if intensified statin treatment was associated with reduced oxLDL in T2D plaques and if oxLDL predicts cardiovascular events, to elucidate whether further plaque oxLDL reduction would be a promising therapeutic target.

Methods

Carotid plaque OxLDL levels and plasma lipoproteins were assessed in 200 patients. Plaque oxLDL was located by immunohistochemistry. Plaque cytokines, cells and scavenger receptor gene expression were quantified by Luminex, immunohistochemistry and RNA sequencing, respectively. Clinical information and events during follow-up were obtained from national registers.

Results

Plaque oxLDL levels correlated with markers of inflammatory activity, endothelial activation and plasma LDL cholesterol (r?=?0.22-0.32 and p???0.01 for all). T2D individuals exhibited lower plaque levels of oxLDL, sLOX-1(a marker of endothelial activation) and plasma LDL cholesterol (p?=?0.001, p?=?0.006 and p?=?0.009). No increased gene expression of scavenger receptors was identified in T2D plaques. The lower oxLDL content in T2D plaques was associated with a greater statin usage (p?=?0.026). Supporting this, a linear regression model showed that statin treatment was the factor with the strongest association to plaque oxLDL and plasma LDL cholesterol (p?ConclusionsThis study points out the importance of statin treatment in affecting plaque biology in T2D. It also implies that other biological components, beyond oxLDL, need to be identified and targeted to further reduce the risk of events among T2D patients receiving statin treatment.

SUBMITTER: Singh P

PROVIDER: S-EPMC7737372 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events.

Singh Pratibha P Goncalves Isabel I Tengryd Christoffer C Nitulescu Mihaela M Persson Ana F AF To Fong F Bengtsson Eva E Volkov Petr P Orho-Melander Marju M Nilsson Jan J Edsfeldt Andreas A

Cardiovascular diabetology 20201214 1

<h4>Background</h4>Type 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has been shown to be increased in T2D plaques and suggested to contribute to plaque ruptures. Despite intensified statin treatment during the last decade the higher risk for events remains. Here, we explored if intensified statin treatment was associated with reduced oxLDL in T2D plaques and if oxLDL predicts cardiovascular events, to elucidate ...[more]

PMID: 33317535

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Dataset Information

Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events.

Background

Methods

Results

Publications

Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events.

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