Ontology highlight
ABSTRACT:
SUBMITTER: Kuenzi BM
PROVIDER: S-EPMC7737474 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kuenzi Brent M BM Park Jisoo J Fong Samson H SH Sanchez Kyle S KS Lee John J Kreisberg Jason F JF Ma Jianzhu J Ideker Trey T
Cancer cell 20201022 5
Most drugs entering clinical trials fail, often related to an incomplete understanding of the mechanisms governing drug response. Machine learning techniques hold immense promise for better drug response predictions, but most have not reached clinical practice due to their lack of interpretability and their focus on monotherapies. We address these challenges by developing DrugCell, an interpretable deep learning model of human cancer cells trained on the responses of 1,235 tumor cell lines to 68 ...[more]