Ontology highlight
ABSTRACT:
SUBMITTER: Villari G
PROVIDER: S-EPMC7737607 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Villari Giulia G Enrico Bena Chiara C Del Giudice Marco M Gioelli Noemi N Sandri Chiara C Camillo Chiara C Fiorio Pla Alessandra A Bosia Carla C Serini Guido G
The EMBO journal 20201120 24
Although subcellular positioning of endosomes significantly impacts on their functions, the molecular mechanisms governing the different steady-state distribution of early endosomes (EEs) and late endosomes (LEs)/lysosomes (LYs) in peripheral and perinuclear eukaryotic cell areas, respectively, are still unsolved. We unveil that such differences arise because, while LE retrograde transport depends on the dynein microtubule (MT) motor only, the one of EEs requires the cooperative antagonism of dy ...[more]