Ontology highlight
ABSTRACT:
SUBMITTER: Winkelmann I
PROVIDER: S-EPMC7737618 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Winklemann Iven I Matsuoka Rei R Meier Pascal F PF Shutin Denis D Zhang Chenou C Orellana Laura L Sexton Ricky R Landreh Michael M Robinson Carol V CV Beckstein Oliver O Drew David D
The EMBO journal 20201029 24
Na<sup>+</sup> /H<sup>+</sup> exchangers (NHEs) are ancient membrane-bound nanomachines that work to regulate intracellular pH, sodium levels and cell volume. NHE activities contribute to the control of the cell cycle, cell proliferation, cell migration and vesicle trafficking. NHE dysfunction has been linked to many diseases, and they are targets of pharmaceutical drugs. Despite their fundamental importance to cell homeostasis and human physiology, structural information for the mammalian NHE w ...[more]