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Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.


ABSTRACT:

Background

Recently, lung cancer has become the most common cause of cancer-related death, several studies indicate that the cytochrome P450 2A13 (CYP2A13) polymorphisms may be correlated with lung cancer susceptibility, but the results have been inconsistent and inconclusive. Therefore, the aim of this meta-analysis is to provide a precise conclusion on the potential association between CYP2A13 polymorphisms and the risk of lung cancer based on case-control studies.

Methods

The PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI) databases will be searched for case-control studies published up to September 2020. Odds ratio (OR) and 95% confidence interval (95% CI) were used to determine the effects of the CYP2A13 polymorphism on lung cancer risk, respectively.

Results

The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.

Conclusion

This meta-analysis will summarize the association between CYP2A13 polymorphisms and the risk of lung cancer.

Inplasy registration number

INPLASY202090102.

SUBMITTER: Ma L 

PROVIDER: S-EPMC7738112 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.

Ma Long L   Jin Gang G   Yang Yi Y   Pang Yao Y   Wang Wenhao W   Zhang Hongyi H   Liu Jiawei J   Wu Peng P   Wang Zequan Z   Wang Kui K   Chang Ruitong R   Li Jialong J   Zhu Zijiang Z  

Medicine 20201201 50


<h4>Background</h4>Recently, lung cancer has become the most common cause of cancer-related death, several studies indicate that the cytochrome P450 2A13 (CYP2A13) polymorphisms may be correlated with lung cancer susceptibility, but the results have been inconsistent and inconclusive. Therefore, the aim of this meta-analysis is to provide a precise conclusion on the potential association between CYP2A13 polymorphisms and the risk of lung cancer based on case-control studies.<h4>Methods</h4>The P  ...[more]

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