Ontology highlight
ABSTRACT:
SUBMITTER: Novacek V
PROVIDER: S-EPMC7738173 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Nováček Vít V McGauran Gavin G Matallanas David D Vallejo Blanco Adrián A Conca Piero P Muñoz Emir E Costabello Luca L Kanakaraj Kamalesh K Nawaz Zeeshan Z Walsh Brian B Mohamed Sameh K SK Vandenbussche Pierre-Yves PY Ryan Colm J CJ Kolch Walter W Fey Dirk D Fey Dirk D
PLoS computational biology 20201203 12
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipitous. Computational predictions alleviate these challenges, but the current approaches suffer from limitations like restricted kinome coverage and inaccuracy. They also typically utilise only local features without reflecting broader interaction cont ...[more]