Ontology highlight
ABSTRACT:
SUBMITTER: Meador WD
PROVIDER: S-EPMC7738185 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Meador William D WD Mathur Mrudang M Sugerman Gabriella P GP Malinowski Marcin M Jazwiec Tomasz T Wang Xinmei X Lacerda Carla Mr CM Timek Tomasz A TA Rausch Manuel K MK
eLife 20201215
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve-extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, w ...[more]