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Current Ovarian Cancer Maintenance Strategies and Promising New Developments.

ABSTRACT: While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of BRCA mutation status, however impact on overall survival is limited. Oliparib was approved for BRCA mutant and BRCA wildtype/homologous recombination deficient patients. This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.

SUBMITTER: Gogineni V

PROVIDER: S-EPMC7738841 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Current Ovarian Cancer Maintenance Strategies and Promising New Developments.

Gogineni Vinaya V Morand Susan S Staats Hannah H Royfman Rachel R Devanaboyina Monika M Einloth Katelyn K Dever Danielle D Stanbery Laura L Aaron Phylicia P Manning Luisa L Walter Adam A Edelman Gerald G Dworkin Lance L Nemunaitis John J

Journal of Cancer 20210101 1

While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of BRCA mutation status, however impact on overall survival is limited. Oliparib was approved for BRCA mutant and BRCA</ ...[more]

PMID: 33391401

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