Dataset Information
Failure patterns and outcomes of dose escalation of stereotactic body radiotherapy for locally advanced pancreatic cancer: a multicenter cohort study.
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ABSTRACT: Objective
This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED10, ?/??=?10) of 60-70?Gy with those of a BED10?>70?Gy for locally advanced pancreatic cancer (LAPC).Methods
Patients from three centers with a biopsy and a radiographically proven LAPC were retrospectively included and data were prospectively collected from June 2012 to June 2019. Radiotherapy was delivered by stereotactic body radiation therapy. Recurrences were categorized as in-field, marginal, and outside-the-field recurrence. Patients in two groups were required to receive abdominal enhanced contrast CT or MRI every 2-3?months and CA19-9 examinations every month during follow-up. Treatment-related toxicities were evaluated every month. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method.Results
After propensity score matching, there were 486 patients in each group. The median prescription dose of the two groups was 37?Gy/5-8?f (range: 36-40.8?Gy/5-8?f) and 42?Gy/5-8?f (range: 40-49.6?Gy/5-8?f), respectively. The median OS of patients with a BED10?>70?Gy and a BED10 60-70?Gy was 20.3?months (95% CI: 19.1-21.5?months) and 18.2?months (95% CI: 17.8-18.6?months) respectively (p?p?10 of 60-70?Gy (in-field: 97/486 versus 72/486, p?=?0.034; marginal: 109/486 versus 84/486, p?=?0.044). However, more patients with BED10?>70?Gy had grade 2 or 3 acute (87/486 versus 64/486, p?=?0.042) and late gastrointestinal toxicities (77/486 versus 55/486, p?=?0.039) than those with BED10 of 60-70?Gy.Conclusion
BED10?>70?Gy was found to have the best survival benefits along with a higher incidence of acute and late gastrointestinal toxicities. Therefore, a higher dose may be required in the case of patients' good tolerance.
SUBMITTER: Zhu X
PROVIDER: S-EPMC7739203 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Failure patterns and outcomes of dose escalation of stereotactic body radiotherapy for locally advanced pancreatic cancer: a multicenter cohort study.
Therapeutic advances in medical oncology 20201214
<h4>Objective</h4>This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED<sub>10</sub>, α/β = 10) of 60-70 Gy with those of a BED<sub>10</sub> >70 Gy for locally advanced pancreatic cancer (LAPC).<h4>Methods</h4>Patients from three centers with a biopsy and a radiographically proven LAPC were retrospectively included and data were prospectively collected from June 2012 to June 2019. Radiotherapy was delivered by stereotactic body radiation therapy. Recurre ...[more]