Dataset Information

Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic.

ABSTRACT:

Background

15% of COVID-19 patients develop severe pneumonia. Non-invasive mechanical ventilation and high-flow nasal cannula can reduce the rate of endotracheal intubation in adult respiratory distress syndrome, although failure rate is high.

Objective

To describe the rate of endotracheal intubation, the effectiveness of treatment, complications and mortality in patients with severe respiratory failure due to COVID-19.

Methods

Prospective cohort study in a first-level hospital in Madrid. Patients with a positive polymerase chain reaction for SARS-CoV-2 and admitted to the Intermediate Respiratory Care Unit with tachypnea, use of accessory musculature or SpO2 <92% despite FiO2> 0.5 were included. Intubation rate, medical complications, and 28-day mortality were recorded. Statistical analysis through association studies, logistic and Cox regression models and survival analysis was performed.

Results

Seventy patients were included. 37.1% required endotracheal intubation, 58.6% suffered medical complications and 24.3% died. Prone positioning was independently associated with lower need for endotracheal intubation (OR 0.05; 95% CI 0.005 to 0.54, p = 0.001). The adjusted HR for death at 28 days in the group of patients requiring endotracheal intubation was 5.4 (95% CI 1.51 to 19.5; p = 0.009).

Conclusions

The rate of endotracheal intubation in patients with severe respiratory failure from COVID-19 was 37.1%. Complications and mortality were lower in patients in whom endotracheal intubation could be avoided. Prone positioning could reduce the need for endotracheal intubation.

SUBMITTER: Carrillo Hernandez-Rubio J

PROVIDER: S-EPMC7743985 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic.

Carrillo Hernandez-Rubio Javier J Sanchez-Carpintero Abad Maria M Yordi Leon Andrea A Doblare Higuera Guillermo G Garcia Rodriguez Leticia L Garcia Torrejon Carmen C Mayor Cacho Alejandro A Jimenez Rodriguez Angel A Garcia-Salmones Martin Mercedes M

PloS one 20201216 12

<h4>Background</h4>15% of COVID-19 patients develop severe pneumonia. Non-invasive mechanical ventilation and high-flow nasal cannula can reduce the rate of endotracheal intubation in adult respiratory distress syndrome, although failure rate is high.<h4>Objective</h4>To describe the rate of endotracheal intubation, the effectiveness of treatment, complications and mortality in patients with severe respiratory failure due to COVID-19.<h4>Methods</h4>Prospective cohort study in a first-level hosp ...[more]

PMID: 33326484

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Dataset Information

Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic.

Background

Objective

Methods

Results

Conclusions

Publications

Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic.

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