Ontology highlight
ABSTRACT:
SUBMITTER: Czajka TF
PROVIDER: S-EPMC7744031 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Czajka Timothy F TF Vance David J DJ Mantis Nicholas J NJ
Trends in microbiology 20201216 3
Camelid-derived and synthetic single-domain antibodies (sdAbs) are emerging as potent weapons against the novel coronavirus, SARS-CoV-2. sdAbs are small, compact, thermostable immunoglobulin elements capable of binding targets with subnanomolar affinities. By leveraging the power of phage- and yeast surface-display technologies, rare sdAbs can be isolated from highly diverse and complex antibody libraries. Once in hand, sdAbs can be engineered to improve binding affinity, avidity, target specifi ...[more]