Dataset Information

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe₃O₄@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid ? (A?) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from A?-mediated neurotoxicity by inhibiting A? aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility. In order to better improve the cell uptake efficiency and bioavailability of CUR and reduce the cytotoxicity of high-dose CUR, a novel CUR delivery system for AD therapy has been constructed based on the employment of the Fe₃O₄@carbon dots nanocomposite (Fe₃O₄@CDs) as the carrier. CUR-Fe₃O₄@CDs have a strong affinity toward A? and effectively inhibit extracellular A? fibrillation. In addition, CUR-Fe₃O₄@CDs can inhibit the production of reactive oxygen species (ROS) mediated by A? fibrils and the corresponding neurotoxicity in PC12 cells. More importantly, it can restore nerve damage and maintained neuronal morphology. These results indicate that the application of CUR-Fe₃O₄@CDs provides a promising platform for the treatment of AD.

SUBMITTER: Kuang Y

PROVIDER: S-EPMC7744485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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A Novel Nanosystem Realizing Curcumin Delivery Based on Fe<sub>3</sub>O<sub>4</sub>@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

Kuang Ying Y Zhang Jingwen J Xiong Mogao M Zeng Weijia W Lin Xiaofeng X Yi Xiaoqing X Luo Yan Y Yang Min M Li Feng F Huang Qitong Q

Frontiers in bioengineering and biotechnology 20201203

Alzheimer's disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Aβ-mediated neurotoxicity by inhibiting Aβ aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility ...[more]

PMID: 33344438

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Project description:Water scarcity is now a serious global issue resulting from population growth, water decrease, and pollution. Traditional wastewater treatment plants are insufficient and cannot meet the basic standards of water quality at reasonable cost or processing time. In this paper we report the preparation, characterization and multiple applications of an efficient photocatalytic nanocomposite (CoxNi1-xFe2O4; x?=?0.9/SiO2/TiO2/C-dots) synthesized by a layer-by-layer method. Then, the photocatalytic capabilities of the synthesized nanocomposite were extensively-studied against aqueous solutions of chloramine-T trihydrate. In addition, reaction kinetics, degradation mechanism and various parameters affecting the photocatalytic efficiency (nanocomposite dose, chloramine-T initial concentration, and reaction pH) were analyzed in detail. Further, the antimicrobial activities of the prepared nanocomposite were tested and the effect of UV-activation on the antimicrobial abilities of the prepared nanocomposite was analyzed. Finally, a comparison between the antimicrobial abilities of the current nanocomposite and our previously-reported nanocomposite (CoxNi1-xFe2O4; x?=?0.9/SiO2/TiO2) had been carried out. Our results revealed that the prepared nanocomposite possessed a high degree of crystallinity, confirmed by XRD, while UV-Vis. recorded an absorption peak at 299 nm. In addition, the prepared nanocomposite possessed BET-surface area of (28.29?±?0.19 m2/g) with narrow pore size distribution. Moreover, it had semi-spherical morphology, high-purity and an average particle size of (19.0 nm). The photocatalytic degradation efficiency was inversely-proportional to chloramine-T initial concentration and directly proportional to the photocatalyst dose. In addition, basic medium (pH 9) was the best suited for chloramine-T degradation. Moreover, UV-irradiation improved the antimicrobial abilities of the prepared nanocomposite against E. coli, B. cereus, and C. tropicalis after 60 min. The observed antimicrobial abilities (high ZOI, low MIC and more efficient antibiofilm capabilities) were unique compared to our previously-reported nanocomposite. Our work offers significant insights into more efficient water treatment and fosters the ongoing efforts looking at how pollutants degrade the water supply and the disinfection of water-borne pathogenic microorganisms.

Dataset Information

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe₃O₄@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

Publications

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe<sub>3</sub>O<sub>4</sub>@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

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A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

Publications

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe<sub>3</sub>O<sub>4</sub>@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe₃O₄@Carbon Dots Nanocomposite for Alzheimer's Disease Therapy.