Ontology highlight
ABSTRACT:
SUBMITTER: Pietzner M
PROVIDER: S-EPMC7744536 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Pietzner Maik M Wheeler Eleanor E Carrasco-Zanini Julia J Raffler Johannes J Kerrison Nicola D ND Oerton Erin E Auyeung Victoria P W VPW Luan Jian'an J Finan Chris C Casas Juan P JP Ostroff Rachel R Williams Steve A SA Kastenmüller Gabi G Ralser Markus M Gamazon Eric R ER Wareham Nicholas J NJ Hingorani Aroon D AD Langenberg Claudia C
Nature communications 20201216 1
Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify new or repurpose existing drugs targeting those proteins. We present a genetic discovery study of 179 such host proteins among 10,708 individuals using an aptamer-based technique. We identify 220 host DNA sequence variants acting in cis (MAF 0.01-49.9%) and explaining 0.3-70.9% of the variance of 97 of these proteins, including 45 with no ...[more]