A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum gram-negative antimicrobial coverage.
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ABSTRACT:
SUBMITTER: Russell CD
PROVIDER: S-EPMC7744989 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage.
Russell Clark D CD Whittaker Ed E Dee Dominic P DP Farquhar Eilidh E Saenz de Villaverde Alba A Evans Morgan H MH Laurenson Ian F IF Mackintosh Claire L CL Cevik Muge M
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20201201 10
Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage. ...[more]
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