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Clinical Evolution of AmpC-Mediated Ceftazidime-Avibactam and Cefiderocol Resistance in Enterobacter cloacae Complex Following Exposure to Cefepime.

ABSTRACT: We report 2 independent patients from whom carbapenem and ceftazidime-avibactam-resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2-amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

SUBMITTER: Shields RK

PROVIDER: S-EPMC7744991 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Clinical Evolution of AmpC-Mediated Ceftazidime-Avibactam and Cefiderocol Resistance in Enterobacter cloacae Complex Following Exposure to Cefepime.

Shields Ryan K RK Iovleva Alina A Kline Ellen G EG Kawai Akito A McElheny Christi L CL Doi Yohei Y

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20201201 10

We report 2 independent patients from whom carbapenem and ceftazidime-avibactam-resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2-amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin. ...[more]

PMID: 32236408

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Structural Basis of Reduced Susceptibility to Ceftazidime-Avibactam and Cefiderocol in Enterobacter cloacae Due to AmpC R2 Loop Deletion.

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Stability and low induction propensity of cefiderocol against chromosomal AmpC ?-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae.

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