Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC7746348 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Zhu Qiankun Q Ren Haiyang H Li Xiaodong X Qian Bo B Fan Shengjie S Hu Fengli F Xu Lishan L Zhai Bo B
Aging 20201116 22
For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance to sorafenib. We used bioinformatics methods to identify genes whose expression was differentially induced by sorafenib and regorafenib in HCC. We identified <i>KIF14</i> as an onco ...[more]