Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7746388 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wang Xiufang X Wu Zhikun Z Qin Wenyan W Sun Tong T Lu Senxu S Li Yalun Y Wang Yuanhe Y Hu Xiaoyun X Xu Dongping D Wu Yutong Y Chen Qiuchen Q Yao Weifan W Liu Mingyan M Wei Minjie M Wu Huizhe H
Aging 20201116 22
Increasing evidence supports long non-coding RNA-ZFAS1 as master protein regulators involved in a variety of human cancers. However, the molecular mechanism is not fully understood in colorectal cancer (CRC) and remains to be elucidated. Here, we uncovered a previously unreported mechanism linking RNA helicase DDX21 regulated by lncRNA ZFAS1 in control of POLR1B expression in CRC initiation and progression. Specifically, ZFAS1 exerted its oncogenic functions and was significantly up-regulated ac ...[more]