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MTOR inhibition impairs extinction memory reconsolidation.


ABSTRACT: Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is necessary for fear-motivated avoidance extinction memory reconsolidation and suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner to maintain the reactivated extinction memory trace.

SUBMITTER: Radiske A 

PROVIDER: S-EPMC7747651 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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mTOR inhibition impairs extinction memory reconsolidation.

Radiske Andressa A   Gonzalez Maria Carolina MC   Nôga Diana A DA   Rossato Janine I JI   Bevilaqua Lia R M LRM   Cammarota Martín M  

Learning & memory (Cold Spring Harbor, N.Y.) 20201215 1


Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibiti  ...[more]

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