Ontology highlight
ABSTRACT:
SUBMITTER: Radiske A
PROVIDER: S-EPMC7747651 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Radiske Andressa A Gonzalez Maria Carolina MC Nôga Diana A DA Rossato Janine I JI Bevilaqua Lia R M LRM Cammarota Martín M
Learning & memory (Cold Spring Harbor, N.Y.) 20201215 1
Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibiti ...[more]