Ontology highlight
ABSTRACT:
SUBMITTER: Kanoldt V
PROVIDER: S-EPMC7747745 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kanoldt Verena V Kluger Carleen C Barz Christiane C Schweizer Anna-Lena AL Ramanujam Deepak D Windgasse Lukas L Engelhardt Stefan S Chrostek-Grashoff Anna A Grashoff Carsten C
Nature communications 20201217 1
Vinculin is a ubiquitously expressed protein, crucial for the regulation of force transduction in cells. Muscle cells express a vinculin splice-isoform called metavinculin, which has been associated with cardiomyopathies. However, the molecular function of metavinculin has remained unclear and its role for heart muscle disorders undefined. Here, we have employed a set of piconewton-sensitive tension sensors to probe metavinculin mechanics in cells. Our experiments reveal that metavinculin bears ...[more]