Ontology highlight
ABSTRACT:
SUBMITTER: Mdluli T
PROVIDER: S-EPMC7748270 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mdluli Thembi T Jian Ningbo N Slike Bonnie B Paquin-Proulx Dominic D Donofrio Gina G Alrubayyi Aljawharah A Gift Syna S Grande Rebecca R Bryson Mary M Lee Anna A Dussupt Vincent V Mendez-Riveria Letzibeth L Sanders-Buell Eric E Chenine Agnès-Laurence AL Tran Ursula U Li Yifan Y Brown Eric E Edlefsen Paul T PT O'Connell Robert R Gilbert Peter P Nitayaphan Sorachai S Pitisuttihum Punnee P Rerks-Ngarm Supachai S Robb Merlin L ML Gramzinski Robert R Alter Galit G Tovanabutra Sodsai S Georgiev Ivelin S IS Ackerman Margaret E ME Polonis Victoria R VR Vasan Sandhya S Michael Nelson L NL Kim Jerome H JH Eller Michael A MA Krebs Shelly J SJ Rolland Morgane M
PLoS pathogens 20201208 12
The RV144 vaccine efficacy clinical trial showed a reduction in HIV-1 infections by 31%. Vaccine efficacy was associated with stronger binding antibody responses to the HIV Envelope (Env) V1V2 region, with decreased efficacy as responses wane. High levels of Ab-dependent cellular cytotoxicity (ADCC) together with low plasma levels of Env-specific IgA also correlated with decreased infection risk. We investigated whether B cell priming from RV144 vaccination impacted functional antibody responses ...[more]