Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.
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ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC7748410 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.
Zhang Qian Q Bastard Paul P Bolze Alexandre A Jouanguy Emmanuelle E Zhang Shen-Ying SY Cobat Aurélie A Notarangelo Luigi D LD Su Helen C HC Abel Laurent L Casanova Jean-Laurent JL
Med (New York, N.Y.) 20201201 1
The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. ...[more]
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