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Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.


ABSTRACT: The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7748410 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

Zhang Qian Q   Bastard Paul P   Bolze Alexandre A   Jouanguy Emmanuelle E   Zhang Shen-Ying SY   Cobat Aurélie A   Notarangelo Luigi D LD   Su Helen C HC   Abel Laurent L   Casanova Jean-Laurent JL  

Med (New York, N.Y.) 20201201 1


The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. ...[more]

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