Deciphering the combinatorial landscape of immunity.
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ABSTRACT:
SUBMITTER: Cappuccio A
PROVIDER: S-EPMC7748411 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Deciphering the combinatorial landscape of immunity.
Cappuccio Antonio A Jensen Shane T ST Hartmann Boris M BM Sealfon Stuart C SC Soumelis Vassili V Zaslavsky Elena E
eLife 20201123
From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes. To understand combinatorial regulation, we present the immune Synergistic/Antagonistic Interaction Learner (iSAIL). iSAIL includes a machine learning classifier to map and interpret interactions, a curated compendium of immunological combination treatment datasets, and their glo ...[more]
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