Ontology highlight
ABSTRACT:
SUBMITTER: Ouzounis CA
PROVIDER: S-EPMC7749296 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Computational and structural biotechnology journal 20201204
The genome of SARS-CoV-2, the coronavirus responsible for the Covid-19 pandemic, encodes a number of accessory genes. The longest accessory gene, Orf3a, plays important roles in the virus lifecycle indicated by experimental findings, known polymorphisms, its evolutionary trajectory and a distinct three-dimensional fold. Here we show that supervised, sensitive database searches with Orf3a detect weak, yet significant and highly specific similarities to the M proteins of coronaviruses. The similar ...[more]