Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC7749742 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Wang Bing B Lim Chuan-Bian CB Yan Jiawei J Li Lizhen L Wang Jufang J Little John B JB Yuan Zhi-Min ZM
Journal of molecular cell biology 20200901 9
A role of tumor-suppressive activity of p53 in the tumor microenvironment (TME) has been implicated but remains fairly understudied. To address this knowledge gap, we leveraged our MdmxS314A mice as recipients to investigate how implanted tumor cells incapacitate host p53 creating a conducive TME for tumor progression. We found that tumor cell-associated stress induced p53 downregulation in peritumor cells via an MDMX-Ser314 phosphorylation-dependent manner. As a result, an immunosuppressive TME ...[more]