Relationships of inflammation trajectories with white matter volume and integrity in midlife.

ABSTRACT:

Objective

Elevated inflammation is associated with worse late-life cognitive functioning and brain health. Our goal was to examine the relationship between inflammation trajectories and white matter integrity in midlife.

Methods

Participants were 508 adults from the Coronary Artery Risk Development in Young Adults Study (CARDIA; 51% female). Latent class analysis was used to identify inflammation trajectories based on repeated measures of the inflammatory marker C-reactive protein (CRP) over the 18 years before brain magnetic resonance imaging (MRI). Outcomes were brain MRI measures of total and region-specific white matter volume and integrity at a mean age of 50.6 ± 3.4 years. Linear regression was used to examine if inflammation trajectories were associated with brain MRI

SUBMITTER: O'Donovan A 

PROVIDER: S-EPMC7749816 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature