Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC7750422 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Zhang Tianran T Li Hongxuan H Ouyang Changhan C Cao Guangqing G Gao Jiangang J Wu Jiliang J Yang Jianmin J Yu Nengwang N Min Qing Q Zhang Cheng C Zhang Wencheng W
Redox biology 20201206
Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation. In addition, growing evidence has indicated that LKB1 functions as a tumor suppressor gene. However, its role in vascular calcification has not been reported. LKB1<sup>flox/flox</sup> mice were hybridized with SM22-CreER<sup>T2</sup> transgenic mice ...[more]