Dataset Information

Successful Antiviral Therapy Reduces Risk of Schizophrenia Among Chronic Hepatitis C Patients: A Nationwide Real-World Taiwanese Cohort (T-COACH).

ABSTRACT:

Background

Chronic hepatitis C (CHC) has been associated with major psychoses, and interferon (IFN)-based therapy may cause psychiatric sequelae. We aimed to evaluate the effects of sustained virological response (SVR) on the incidence of major psychoses in a nationwide Taiwanese CHC cohort.

Methods

Fifteen thousand eight hundred thirty-six CHC Taiwanese who received IFN-based therapy were enrolled between 2003 and 2015. Of those, 12?723 patients were linked to the National Health Insurance Research Databases for the incidence of major psychoses. Death before major psychoses was considered a competing risk.

Results

Twenty-four patients developed new-onset major psychoses during 67?554 person-years (3.6 per 10?000 person-years), including 16 affective psychoses, 7 schizophrenia, and 1 organic psychotic condition. The incidence of major psychoses and affective psychoses did not differ between the SVR and non-SVR groups. The 10-year cumulative incidence of schizophrenia were significantly higher in the non-SVR than in SVR patients (0.14% vs 0.04%, P?=?.036). Cox subdistribution hazards showed that SVR and older age were associated with a significantly lower risk of schizophrenia (hazard ratio =?0.18 and 0.17). Sustained virological response was associated with decreased incidence of schizophrenia and majorly observed among patients with age <45 (P?=?.02).

Conclusions

Successful IFN-based therapy might reduce the incidence of schizophrenia among CHC patients, especially among younger patients.

SUBMITTER: Tsai PC

PROVIDER: S-EPMC7751132 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Successful Antiviral Therapy Reduces Risk of Schizophrenia Among Chronic Hepatitis C Patients: A Nationwide Real-World Taiwanese Cohort (T-COACH).

Tsai Pei-Chien PC Chen Chi-Yi CY Kuo Hsing-Tao HT Hung Chao-Hung CH Tseng Kuo-Chih KC Lai Hsueh-Chou HC Peng Cheng-Yuan CY Wang Jing-Houng JH Chen Jyh-Jou JJ Lee Pei-Lun PL Chien Rong-Nan RN Yang Chi-Chieh CC Lo Gin-Ho GH Kao Jia-Horng JH Liu Chun-Jen CJ Liu Chen-Hua CH Yan Sheng-Lei SL Bair Ming-Jong MJ Lin Chun-Yen CY Su Wei-Wen WW Chu Cheng-Hsin CH Chen Chih-Jen CJ Tung Shui-Yi SY Tai Chi-Ming CM Lin Chih-Wen CW Lo Ching-Chu CC Cheng Pin-Nan PN Chiu Yen-Cheng YC Wang Chia-Chi CC Cheng Jin-Shiung JS Tsai Wei-Lun WL Lin Han-Chieh HC Huang Yi-Hsiang YH Yeh Ming-Lun ML Huang Chung-Feng CF Hsieh Meng-Hsuan MH Huang Jee-Fu JF Dai Chia-Yen CY Chung Wan-Long WL Ke Chiao-Li Khale CK Yu Ming-Lung ML

Open forum infectious diseases 20200831 10

<h4>Background</h4>Chronic hepatitis C (CHC) has been associated with major psychoses, and interferon (IFN)-based therapy may cause psychiatric sequelae. We aimed to evaluate the effects of sustained virological response (SVR) on the incidence of major psychoses in a nationwide Taiwanese CHC cohort.<h4>Methods</h4>Fifteen thousand eight hundred thirty-six CHC Taiwanese who received IFN-based therapy were enrolled between 2003 and 2015. Of those, 12 723 patients were linked to the National Health ...[more]

PMID: 33376753

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Dataset Information

Successful Antiviral Therapy Reduces Risk of Schizophrenia Among Chronic Hepatitis C Patients: A Nationwide Real-World Taiwanese Cohort (T-COACH).

Background

Methods

Results

Conclusions

Publications

Successful Antiviral Therapy Reduces Risk of Schizophrenia Among Chronic Hepatitis C Patients: A Nationwide Real-World Taiwanese Cohort (T-COACH).

Similar Datasets

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