Dataset Information

Acute Exercise Effects Predict Training Change in Cognition and Connectivity.

ABSTRACT:

Purpose

Previous studies report memory and functional connectivity of memory systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects of aerobic exercise may reflect initial changes that adapt over time. In this trial, for the first time, we test the proof-of-concept of whether the acute and training effects of aerobic exercise on working memory and brain network connectivity are related in the same participants.

Methods

Cognitively normal older participants (N = 34) were enrolled in a randomized clinical trial (NCT02453178). Participants completed fMRI resting state and a face working memory N-back task acutely after light- and moderate-intensity exercises and after a 12-wk aerobic training intervention.

Results

Functional connectivity did not change more after moderate-intensity training compared with light-intensity training. However, both training groups showed similar changes in cardiorespiratory fitness (CRF) (maximal exercise oxygen uptake, V?O2peak), limiting group-level comparisons. Acute effects of moderate-intensity aerobic exercise on connections primarily in the default network predicted training enhancements in the same connections. Working memory also improved acutely, especially after moderate-intensity, and greater acute improvements predicted greater working memory improvement with training. Exercise effects on functional connectivity of right lateralized frontoparietal connections were related to both acute and training gains in working memory.

Conclusions

Our data support the concept of acute aerobic exercise effects on functional brain systems and performance as an activity-evoked biomarker for exercise training benefits in the same outcomes. These findings may lead to new insights and methods for improving memory outcomes with aerobic exercise training.

SUBMITTER: Voss MW

PROVIDER: S-EPMC7753185 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Acute Exercise Effects Predict Training Change in Cognition and Connectivity.

Voss Michelle W MW Weng Timothy B TB Narayana-Kumanan Krithika K Cole Rachel C RC Wharff Conner C Reist Lauren L Dubose Lyndsey L Sigurdsson Gardar G Mills James A JA Long Jeffrey D JD Magnotta Vincent A VA Pierce Gary L GL

Medicine and science in sports and exercise 20200101 1

<h4>Purpose</h4>Previous studies report memory and functional connectivity of memory systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects of aerobic exercise may reflect initial changes that adapt over time. In this trial, for the first time, we test the proof-of-concept of whether the acute and training effects of aerobic exercise on working memory and brain network connectivity are related in the same participants.<h4>Methods</h4>C ...[more]

PMID: 31385912

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Project description:BackgroundAlthough studies have demonstrated that physical exercise alters homocysteine levels in the blood, meta-analyses of the effects of acute exercise and exercise training on homocysteine blood concentration have not been performed, especially regarding the duration and intensity of exercise, which could affect homocysteine levels differently.ObjectiveThe aim of this meta-analysis was to ascertain the effects of acute exercise and exercise training on homocysteine levels in the blood.MethodA review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses using the online databases PubMed, SPORTDiscus, and SciELO to identify relevant studies published through June 2015. Review Manager was used to calculate the effect size of acute exercise and exercise training using the change in Hcy plasmaserum concentration from baseline to post-acute exercise and trained vs. sedentary control groups, respectively. Weighted mean differences were calculated using random effect models.ResultsGiven the abundance of studies, acute exercise trials were divided into two subgroups according to exercise volume and intensity, whereas the effects of exercise training were analyzed together. Overall, 22 studies with a total of 520 participants indicated increased plasma homocysteine concentration after acute exercise (1.18 ?mol/L, 95% CI: 0.71 to 1.65, p < .01). Results of a subgroup analysis indicated that either long-term exercise of low-to-moderate intensity (1.39 ?mol/L, 95% CI: 0.9 to 1.89, p < .01) or short-term exercise of high intensity (0.83 ?mol/L, 95% CI: 0.19 to 1.40, p < .01) elevated homocysteine levels in the blood. Increased homocysteine induced by exercise was significantly associated with volume of exercise, but not intensity. By contrast, resistance training reduced plasma homocysteine concentration (-1.53 ?mol/L, 95% CI: -2.77 to -0.28, p = .02), though aerobic training did not. The cumulative results of the seven studies with a total of 230 participants in exercise training analysis did not demonstrate a significant impact on homocysteine levels in the blood (-0.56 ?mol/L, 95% CI: -1.61 to 0.50, p = .23).ConclusionsCurrent evidence demonstrates that acute exercise increases homocysteine levels in the blood independent of exercise duration and intensity. Resistance, but not aerobic training decreases plasma homocysteine levels.

Dataset Information

Acute Exercise Effects Predict Training Change in Cognition and Connectivity.

Purpose

Methods

Results

Conclusions

Publications

Acute Exercise Effects Predict Training Change in Cognition and Connectivity.

Similar Datasets

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