The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer.
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ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC7753359 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer.
Shi Yi Y Riese David J DJ Shen Jianzhong J
Frontiers in pharmacology 20201208
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of CXCL12 and its receptors subsequently induces downstream signaling pathways with broad effects on chemotaxis, cell proliferation, migration, and gene expression. Accumulating evidence suggests that the CXCL12/CXCR4/CXCR7 axis plays a pivotal rol ...[more]
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