Dataset Information

Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study.

ABSTRACT:

Objectives

The aims of this study are to report the prevalence of delirium on admission to the unit in patients hospitalized with SARS-CoV-2 infection, to identify the factors associated with delirium, and to evaluate the association between delirium and in-hospital mortality.

Design

Multicenter observational cohort study.

Settings

Acute medical units in four Italian hospitals.

Participants

A total of 516 patients (median age 78?years) admitted to the participating centers with SARS-CoV-2 infection from February 22 to May 17, 2020.

Measurements

Comprehensive medical assessment with detailed history, physical examinations, functional status, laboratory and imaging procedures. On admission, delirium was determined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition) criteria, 4AT, m-Richmond Agitation Sedation Scale, or clinical impression depending on the site. The primary outcomes were delirium rates and in-hospital mortality.

Results

Overall, 73 (14.1%, 95% confidence interval (CI) = 11.0-17.3%) patients presented delirium on admission. Factors significantly associated with delirium were dementia (odds ratio, OR = 4.66, 95% CI = 2.03-10.69), the number of chronic diseases (OR = 1.20, 95% CI = 1.03; 1.40), and chest X-ray or CT opacity (OR = 3.29, 95% CI = 1.12-9.64 and 3.35, 95% CI = 1.07-10.47, for multiple or bilateral opacities and single opacity vs no opacity, respectively). There were 148 (33.4%) in-hospital deaths in the no-delirium group and 43 (58.9%) in the delirium group (P-value assessed using the Gray test <.001). As assessed by a multivariable Cox model, patients with delirium on admission showed an almost twofold increased hazard ratio for in-hospital mortality with respect to patients without delirium (hazard ratio = 1.88, 95% CI = 1.25-2.83).

Conclusion

Delirium is prevalent and associated with in-hospital mortality among older patients hospitalized with SARS-CoV-2 infection.

SUBMITTER: Rebora P

PROVIDER: S-EPMC7753490 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study.

Rebora Paola P Rozzini Renzo R Bianchetti Angelo A Blangiardo Paolo P Marchegiani Alice A Piazzoli Andrea A Mazzeo Francesca F Cesaroni Giulia G Chizzoli Anita A Guerini Fabio F Bonfanti Paolo P Morandi Alessandro A Faraci Bianca B Gentile Simona S Bna Claudio C Savelli Giordano G Citerio Giuseppe G Valsecchi Maria Grazia MG Mazzola Paolo P Bellelli Giuseppe G

Journal of the American Geriatrics Society 20201208 2

<h4>Objectives</h4>The aims of this study are to report the prevalence of delirium on admission to the unit in patients hospitalized with SARS-CoV-2 infection, to identify the factors associated with delirium, and to evaluate the association between delirium and in-hospital mortality.<h4>Design</h4>Multicenter observational cohort study.<h4>Settings</h4>Acute medical units in four Italian hospitals.<h4>Participants</h4>A total of 516 patients (median age 78 years) admitted to the participating c ...[more]

PMID: 33411332

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Dataset Information

Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study.

Objectives

Design

Settings

Participants

Measurements

Results

Conclusion

Publications

Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study.

Similar Datasets

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