Dataset Information

Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic.

ABSTRACT: To investigate the relationship between Bacille Calmette-Guérin (BCG) vaccination and SARS-CoV-2 by a bioinformatics approach, two datasets for the SARS-CoV-2 infection group and BCG-vaccinated group were downloaded. Differentially Expressed Genes were identified. Gene ontology and pathways were functionally enriched, and networking was constructed in NetworkAnalyst. Lastly, the correlation between post-BCG vaccination and COVID-19 transcriptome signatures was established. A total of 161 DEGs (113 upregulated DEGs and 48 downregulated genes) were identified in the SARS-CoV-2 group. In the pathway enrichment analysis, a cross-reference of upregulated Kyoto Encyclopedia of Genes and Genomes pathways in SARS-CoV-2 with downregulated counterparts in the BCG-vaccinated group, resulted in the intersection of 45 common pathways, accounting for 86.5% of SARS-CoV-2 upregulated pathways. Of these intersecting pathways, a vast majority were immune and inflammatory pathways with top significance in interleukin-17, tumor necrosis factor, NOD-like receptors, and nuclear factor-κB signaling pathways. Given the inverse relationship of the specific differentially expressed gene pathways highlighted in our results, the BCG-vaccine may play a protective role against COVID-19 by mounting a nonspecific immunological response and further investigation of this relationship is warranted.

SUBMITTER: Toraih EA

PROVIDER: S-EPMC7753709 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic.

Toraih Eman A EA Sedhom Jessica A JA Dokunmu Titilope M TM Hussein Mohammad H MH Ruiz Emmanuelle M L EML Muthusamy Kunnimalaiyaan K Zerfaoui Mourad M Kandil Emad E

Journal of medical virology 20201217 4

To investigate the relationship between Bacille Calmette-Guérin (BCG) vaccination and SARS-CoV-2 by a bioinformatics approach, two datasets for the SARS-CoV-2 infection group and BCG-vaccinated group were downloaded. Differentially Expressed Genes were identified. Gene ontology and pathways were functionally enriched, and networking was constructed in NetworkAnalyst. Lastly, the correlation between post-BCG vaccination and COVID-19 transcriptome signatures was established. A total of 161 DEGs (1 ...[more]

PMID: 33289122

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Dataset Information

Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic.

Publications

Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic.

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