Ontology highlight
ABSTRACT:
SUBMITTER: Wojtyniak M
PROVIDER: S-EPMC7754139 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20200828 22
Oligonucleotides (ON) are promising therapeutic candidates, for instance by blocking endogenous mRNA (antisense mechanism). However, ON usually require structural modifications of the native nucleic acid backbone to ensure satisfying pharmacokinetic properties. One such strategy to design novel antisense oligonucleotides is to replace native phosphate diester units by positively charged artificial linkages, thus leading to (partially) zwitterionic backbone structures. Herein, we report a "gapmer ...[more]