Ontology highlight
ABSTRACT:
SUBMITTER: Daniels B
PROVIDER: S-EPMC7754424 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Daniels Brian B Wunder Christian C Chen Vanessa V Renz Malte M
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20200618 11
Although photoactivated localization microscopy offers the potential to interrogate protein interactions in the physiological environment of a cell, uncertainties in the detection efficiency of photoactivatable proteins lead to complications with data interpretation. Here, we present a numerical model that provides probabilities to detect neighboring molecules dependent on their oligomerization status, density, detection efficiency, and radius, and can be used to assess oligomeric states or dete ...[more]