Ontology highlight
ABSTRACT:
SUBMITTER: Yusoh NA
PROVIDER: S-EPMC7754470 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Yusoh Nur Aininie NA Ahmad Haslina H Gill Martin R MR
ChemMedChem 20200910 22
Platinum drugs are heavily used first-line chemotherapeutic agents for many solid tumours and have stimulated substantial interest in the biological activity of DNA-binding metal complexes. These complexes generate DNA lesions which trigger the activation of DNA damage response (DDR) pathways that are essential to maintain genomic integrity. Cancer cells exploit this intrinsic DNA repair network to counteract many types of chemotherapies. Now, advances in the molecular biology of cancer has pave ...[more]