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The role of NO in COVID-19 and potential therapeutic strategies.

ABSTRACT: Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.

SUBMITTER: Fang W

PROVIDER: S-EPMC7754882 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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The role of NO in COVID-19 and potential therapeutic strategies.

Fang Wanyi W Jiang Jingrui J Su Lei L Shu Tong T Liu Huan H Lai Shenghan S Ghiladi Reza A RA Wang Jun J

Free radical biology & medicine 20201222

Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of ...[more]

PMID: 33347987

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