Dataset Information

Associations of region-specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure.

ABSTRACT:

Aims

Excessive visceral adiposity (VAT) plays an essential role in metabolic derangements with those close to heart further mediates myocardial homeostasis. The disparate biological links between region-specific VAT and cardiometabolic profiles as mediators influencing atrial kinetics remain unexplored.

Methods and results

Among 1326 asymptomatic individuals, region-specific VAT including peri-aortic root fat (PARF) and total pericardial fat (PCF) of cardiac region, together with thoracic peri-aortic adipose tissue (TAT), was assessed using multiple-detector computed tomography. VAT measures were related to functional left atrial (LA) metrics assessed by speckle-tracking algorithm and clinical outcomes of atrial fibrillation (AF) and heart failure (HF). Multivariate linear regression models incorporating body fat, metabolic syndrome, and E/TDI-e' consistently demonstrated independent associations of larger PARF/PCF with peak atrial longitudinal systolic strain (PALS) reduction, higher LA stiffness, and worsened strain rate components; instead, TAT was independently associated with cardiometabolic profiles. PARF rather than PCF or TAT conferred independent prognostic values for incident AF/HF by multivariate Cox regression (adjusted hazard ratio: 1.56, 95% confidence interval: 1.17-2.08, P = 0.002) during a median of 1790 days (interquartile range: 25th to 75th: 1440-1927 days) of follow-up, with subjects categorized into worst PALS and largest VAT tertiles demonstrating highest events (all log-rank P < 0.001). Mediation analysis showed that higher triglyceride and lower high-density lipoproteins may serve as intermediary factors for effects between VAT and LA functional metrics, with lesser role by glucose level.

Conclusions

Visceral adiposity surrounding atrial region was tightly associated with subclinical atrial dysfunction and incident AF or HF beyond metabolic factors. Instead, peri-aortic adiposity may mediate their toxic effects mainly through circulating cardiometabolic profiles.

SUBMITTER: Huang BH

PROVIDER: S-EPMC7754950 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Associations of region-specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure.

Huang Bo-Han BH Chang Shun-Chuan SC Yun Chun-Ho CH Sung Kuo-Tzu KT Lai Yau-Huei YH Lo Chi-In CI Huang Wen-Hung WH Chien Shih-Chieh SC Liu Lawrence Yu-Min LY Hung Ta-Chuan TC Kuo Jen-Yuan JY Lin Jiun-Lu JL Bulwer Bernard B Hou Charles Jia-Yin CJ Chen Ying-Ju YJ Su Cheng-Huang CH Yeh Hung-I HI Hung Chung-Lieh CL

ESC heart failure 20201028 6

<h4>Aims</h4>Excessive visceral adiposity (VAT) plays an essential role in metabolic derangements with those close to heart further mediates myocardial homeostasis. The disparate biological links between region-specific VAT and cardiometabolic profiles as mediators influencing atrial kinetics remain unexplored.<h4>Methods and results</h4>Among 1326 asymptomatic individuals, region-specific VAT including peri-aortic root fat (PARF) and total pericardial fat (PCF) of cardiac region, together with ...[more]

PMID: 33113275

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Dataset Information

Associations of region-specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure.

Aims

Methods and results

Conclusions

Publications

Associations of region-specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure.

Similar Datasets

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