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Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction.

ABSTRACT: A constant current protocol, employing undivided cells, a remarkably low supporting electrolyte concentration, inexpensive electrode materials, and a straightforward precursor synthesis enabling a novel access to N-protected carbazoles by anodic N,C bond formation using directly generated amidyl radicals is reported. Scalability of the reaction is demonstrated and an easy deblocking of the benzoyl protecting group is presented.

SUBMITTER: Kehl A

PROVIDER: S-EPMC7756279 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction.

Kehl Anton A Schupp Niclas N Breising Valentina M VM Schollmeyer Dieter D Waldvogel Siegfried R SR

Chemistry (Weinheim an der Bergstrasse, Germany) 20201029 68

A constant current protocol, employing undivided cells, a remarkably low supporting electrolyte concentration, inexpensive electrode materials, and a straightforward precursor synthesis enabling a novel access to N-protected carbazoles by anodic N,C bond formation using directly generated amidyl radicals is reported. Scalability of the reaction is demonstrated and an easy deblocking of the benzoyl protecting group is presented. ...[more]

PMID: 32737905

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