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UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow.


ABSTRACT: A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

SUBMITTER: Green L 

PROVIDER: S-EPMC7756889 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow.

Green Luke L   Livingstone Keith K   Bertrand Sophie S   Peace Simon S   Jamieson Craig C  

Chemistry (Weinheim an der Bergstrasse, Germany) 20201012 65


A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids. ...[more]

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