Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms.
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ABSTRACT:
SUBMITTER: Chung WC
PROVIDER: S-EPMC7756968 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Loss of <i>Jag1</i> cooperates with oncogenic <i>Kras</i> to induce pancreatic cystic neoplasms.
Chung Wen-Cheng WC Challagundla Lavanya L Zhou Yunyun Y Li Min M Atfi Azeddine A Xu Keli K
Life science alliance 20201202 2
Notch signaling exerts both oncogenic and tumor-suppressive functions in the pancreas. In this study, deletion of <i>Jag1</i> in conjunction with oncogenic <i>Kras</i> <sup>G12D</sup> expression in the mouse pancreas induced rapid development of acinar-to-ductal metaplasia and early stage pancreatic intraepithelial neoplasm; however, culminating in cystic neoplasms rather than ductal adenocarcinoma. Most cystic lesions in these mice were reminiscent of serous cystic neoplasm, and the rest resemb ...[more]
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