MYC dysfunction modulates stemness and tumorigenesis in breast cancer.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7757029 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
MYC dysfunction modulates stemness and tumorigenesis in breast cancer.
Liu Yiqiu Y Zhu Chengjun C Tang Lin L Chen Qin Q Guan Nan N Xu Kun K Guan Xiaoxiang X
International journal of biological sciences 20210101 1
As a transcription factor and proto-oncogene, MYC is known to be deregulated in a variety of tumors, including breast cancer. However, no consistent conclusion on the role and mechanism of MYC deregulation during breast cancer carcinogenesis has been formed. Here, we used the UALCAN, bc-GenExMiner, TCGA, cBioportal, STRING and Kaplan-Meier Plotter databases to explore the mRNA expression, prognosis, transcriptional profile changes, signal pathway rewiring and interaction with the cancer stem cel ...[more]
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