Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy.

ABSTRACT: Gliomas are one of the most common types of primary brain tumors. Despite recent advances in the combination of surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy) and supportive therapy in the multimodal treatment of gliomas, the overall prognosis remains poor and the long‑term survival rate is low. Thus, it is crucial to develop a novel glioma management method. Due to its relatively non‑invasive, selective and repeatable characteristics, photodynamic therapy (PDT) has been investigated for glioma therapy in the past decade, exhibiting higher selectivity and lower side effects compared with those of conventional therapy. However, most of the photosensitizers (PSs) are highly hydrophobic, leading to poor water solubility, rapid degradation with clearance in blood circ

SUBMITTER: Xu D 

PROVIDER: S-EPMC7757081 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature