Safety Aspects of a Randomized Clinical Trial of Maternal and Infant Vitamin D Supplementation by Feeding Type Through 7 Months Postpartum.

ABSTRACT: Background: The safety of higher dose vitamin D (vitD) supplementation in women who change from exclusive or full breastfeeding to combination feeding or who continue supplementation after cessation of breastfeeding is unknown. Objective: Compare vitD supplementation safety of 6,400 to 400 IU/day and 2,400 IU/day using specific laboratory parameters in postpartum women and their infants through 7 months postpartum by feeding type. Design: In this randomized controlled trial, mothers (exclusively breastfeeding or formula-feeding) were randomized at 4-6 weeks' postpartum to 400, 2,400, or 6,400 IU vitD₃ (cholecalciferol)/day for 6 months. Breastfeeding infants in 400 IU group received oral 400 IU vitD₃/day; infants in 2,400 and

SUBMITTER: Wagner CL 

PROVIDER: S-EPMC7757584 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature