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Movement and specificity in a modular DNA binding protein.

ABSTRACT: The single-stranded DNA (ssDNA) binding protein RPA binds to and protects ssDNA while simultaneously recruiting numerous replication and repair proteins essential for genome integrity. In this issue of Structure, Brosey et al. (2015) show that the flexibility and interactions of the modular domains of RPA are altered by ssDNA binding and suggest that these changes in configurational freedom are important for the many functions of RPA.

SUBMITTER: Liptak C 

PROVIDER: S-EPMC7757790 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Movement and specificity in a modular DNA binding protein.

Liptak Cary C   Loria J Patrick JP  

Structure (London, England : 1993) 20150601 6

The single-stranded DNA (ssDNA) binding protein RPA binds to and protects ssDNA while simultaneously recruiting numerous replication and repair proteins essential for genome integrity. In this issue of Structure, Brosey et al. (2015) show that the flexibility and interactions of the modular domains of RPA are altered by ssDNA binding and suggest that these changes in configurational freedom are important for the many functions of RPA. ...[more]

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