Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study.

ABSTRACT:

Background

A second wave of COVID-19 cases in autumn, 2020, in England led to localised, tiered restrictions (so-called alert levels) and, subsequently, a second national lockdown. We examined the impact of these tiered restrictions, and alternatives for lockdown stringency, timing, and duration, on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and hospital admissions and deaths from COVID-19.

Methods

We fit an age-structured mathematical model of SARS-CoV-2 transmission to data on hospital admissions and hospital bed occupancy (ISARIC4C/COVID-19 Clinical Information Network, National Health Service [NHS] England), seroprevalence (Office for National Statistics, UK Biobank, REACT-2 study), virology (REACT-1 study), and deaths (Public Health Englan

SUBMITTER: Davies NG 

PROVIDER: S-EPMC7758181 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature