Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimoto S
PROVIDER: S-EPMC7758185 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Yoshimoto Shohei S Morita Hiromitsu H Matsuda Miho M Katakura Yoshinori Y Hirata Masato M Hashimoto Shuichi S
Laboratory investigation; a journal of technical methods and pathology 20200908 1
Epidermal growth factor receptor (EGFR) is highly expressed in several types of cancer cells including oral squamous cell carcinoma (OSCC). EGF/EGFR signaling is recognized as an important molecular target in cancer therapy. However, cancer cells often become tolerant to EGF/EGFR signaling-targeted therapies. In the tumor microenvironment, the tumor incites inflammation and the inflammation-derived cytokines make a considerable impact on cancer development. In addition, hyperosmolarity is also i ...[more]