Ontology highlight
ABSTRACT:
SUBMITTER: Kalafati L
PROVIDER: S-EPMC7758500 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Kalafati Lydia L Mitroulis Ioannis I Verginis Panayotis P Chavakis Triantafyllos T Kourtzelis Ioannis I
Frontiers in oncology 20201210
Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on ...[more]