Ontology highlight
ABSTRACT:
SUBMITTER: Munro DAD
PROVIDER: S-EPMC7758622 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Munro David A D DAD Bradford Barry M BM Mariani Samanta A SA Hampton David W DW Vink Chris S CS Chandran Siddharthan S Hume David A DA Pridans Clare C Priller Josef J
Development (Cambridge, England) 20201215 23
The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated macrophages (BAMs). Microglia, but not BAMs, were reported to be absent in mice lacking a conserved <i>Csf1r</i> enhancer: the <i>fms</i>-intronic regulatory element (FIRE). However, it is unknown whether FIRE deficiency also impacts BAM arrival and/or maintenance<i>.</i> Here, we show that macrophages in the ventricular system of the brain, includi ...[more]