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Performance evaluation of antibody-based point-of-care devices intended for the identification of immune responses to SARS-CoV-2.


ABSTRACT: The novel coronavirus outbreak caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) was first identified in December of 2019 in Wuhan, China. The local outbreak quickly rose to pandemic level that has spread to more than 188 countries with more than 19 million cases and 732,467 deaths worldwide. The current recommendation for testing is RT-PCR based tests of nasopharyngeal or alternatively nasal- and/or oropharyngeal swabs that detects infection with SARS-CoV-2 to diagnose acute infection. However, there is an urgent need for a quick and accurate antibody-based point-of-care test method to quickly identify evidence of SARS-CoV-2 infection among people who might be missed through active case finding and surveillance efforts. Serology tests measure the presence of antibodies in serum after infection. Here we compared the performance characteristics of 6 commercially available antibody-based point-of-care devices and their potential for identification of individuals infected at some time by SARS-CoV-2.

SUBMITTER: Furuya AKM 

PROVIDER: S-EPMC7758720 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Performance evaluation of antibody-based point-of-care devices intended for the identification of immune responses to SARS-CoV-2.

Furuya Andrea K M AKM   Wagner Christine C   Connors Julia J   Bodnar Janine J   Miller Thomas T   Ryman Nko Lea NL   Warszycki Casey J CJ   Wong Susan J SJ   Walsh Anne C AC   McDonough Kathleen A KA   Lee William T WT  

Diagnostic microbiology and infectious disease 20201224 4


The novel coronavirus outbreak caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) was first identified in December of 2019 in Wuhan, China. The local outbreak quickly rose to pandemic level that has spread to more than 188 countries with more than 19 million cases and 732,467 deaths worldwide. The current recommendation for testing is RT-PCR based tests of nasopharyngeal or alternatively nasal- and/or oropharyngeal swabs that detects infection with SARS-CoV-2 to diagnose ac  ...[more]

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