Dataset Information
Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.
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ABSTRACT: Purpose of review
To review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer.Recent findings
Recently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3-IIB cervical cancer. When these studies were combined (N?=?1259), NACT + RH was associated with a shorter disease-free survival [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.13-1.64], but with a similar overall survival (HR 1.11, 95% CI 0.90-1.36) when compared with the findings for CCRT. Stage-specific analysis for stage IIB cervical cancer demonstrated that disease-free survival was significantly worse with NACT + RH than with CCRT (HR 1.90, 95% CI 1.25-2.89); however, no significant difference was observed for stage IB3-IIA cervical cancer. Based on the results of recent level I evidence, the standard treatment for stage IIB cervical cancer remains CCRT.
SUBMITTER: Matsuzaki S
PROVIDER: S-EPMC7759090 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.
Current oncology reports 20200212 3
<h4>Purpose of review</h4>To review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer.<h4>Recent findings</h4>Recently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3-IIB cervical cancer. When these studies were combined (N = 1259), NACT + RH was associated with a shorter disease-free surv ...[more]